Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.

Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.

Amine N-acetylation in the pineal gland is of special importance because it is the first step in the synthesis of melatonin from serotonin. In the present study the N-acetylation of arylamines and arylalkylamines by homogenates of rat and sheep pineal glands was investigated. The arylamines studied were p-phenetidine and aniline; the arylalkylamines studied were tryptamine, serotonin, 5-methoxy...

Arylalkylamine N-acetyltransferase: "the Timezyme".

Arylalkylamine N-acetyltransferase controls daily changes in melatonin production by the pineal gland and thereby plays a unique role in biological timing in vertebrates. Arylalkylamine N-acetyltransferase is also expressed in the retina, where it may play other roles in addition to signaling, including neurotransmission and detoxification. Large changes in activity reflect cyclic 3',5'-adenosi...

Arylamine N-acetyltransferase.

304 3.5. Namboodiri. kl. A. A,. Nakai. C‘. k Klein, 1). C. (1070) J. Ncurochem. 33. 807-810 30. Klein. 1). C’. k Namboodiri, M. A. A. (1082) Trends Biochem. Sci. 7, OXI02 37. Namboodiri, M. A. A,, Weller, J. I , . Kc Klein, I). C’. (1080) J. l k l . Cheni. 255. 6032-0035 38. Namboodiri, M. A. A,. Weller, J. I, . K: Klein, I). C’. ( 1080) Hiochem. Hiophys. Kes. C’ommun. 96, 1 8%1 05 30 . Niimboo...

NAT 2 ( N - acetyltransferase 2 ( arylamine N - acetyltransferase ) )

NAT 1 ( N - acetyltransferase 1 ( arylamine N - acetyltransferase ) )

The human NAT1 gene has nine exons. The coding region is located in exon 9 and spans 870 bp. Diverse NAT1 transcripts have been reported and two promoters exist. The first promoter, designated as P1 is located in the 5' flanking region of exon 1 and controls two major (a1 and a2) transcripts. The second promoter is located upstream of exon 4 and give rise to at least five (b1 to b5) different t...